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PKM2 inhibitor
CAS No. 94164-88-2
PKM2 inhibitor ( PKM2 inhibitor; MDK4882 )
产品货号. M19274 CAS No. 94164-88-2
PKM2 inhibitor(Compound 3K) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.
纯度: 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥381 | 有现货 |
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| 5MG | ￥624 | 有现货 |
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| 10MG | ￥948 | 有现货 |
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| 25MG | ￥1750 | 有现货 |
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| 50MG | ￥3013 | 有现货 |
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| 100MG | ￥4828 | 有现货 |
|
| 200MG | ￥6901 | 有现货 |
|
| 500MG | ￥10368 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称PKM2 inhibitor
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述PKM2 inhibitor(Compound 3K) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.
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产品描述MDK4882, also known as PKM2 inhibitor or compound 3k, is a PKM2 inhibitor. MDK4882 was first described in Eur J Med Chem. 2017;138:343-352. Currently there is no formal name. We temporarily name it MDK4882 for the convenience of communication, in which the last 4 digit of CAS# is used. MDK4882 displayed more potent PKM2 inhibitory activity than the reported optimal PKM2 inhibitor shikonin. MDK4882 also showed nanomolar antiproliferative activity toward a series of cancer cell lines with high expression of PKM2 including HCT116, Hela and H1299 with IC50 values ranging from 0.18 to 1.56 μM. MDK4882 exhibited more cytotoxicity on cancer cells than normal cells.
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同义词PKM2 inhibitor; MDK4882
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通路Others
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靶点Other Targets
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受体PKM1; PKM2
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研究领域——
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适应症——
化学信息
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CAS Number94164-88-2
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分子量345.48
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分子式C18H19NO2S2
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纯度98%
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溶解度DMSO : 5.56 mg/mL 16.09 mM; H2O : < 0.1 mg/mL
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SMILESCC1=C(C(=O)c2ccccc2C1=O)CSC(=S)N1CCCCC1
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化学全称(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl piperidine-1-carbodithioate
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Ning X, et al. Eur J Med Chem. 2017 Sep 29;138:343-352.
